Odho was born in Karachi, Pakistan on February 12, 1968. She is married, and has three children. She started her professional life as a make-up artist and hairstylist in 1989. While working as a make-up artist for various advertising agencies in Karachi, she was discovered by television personality, Anwar Maqsood. She starred in his play, "Sitara Aur Mehrunissa" in 1993; the role turned her into a household name in Pakistan. In 1995, she made her film debut in Jo Darr Gya Woh Marr Gya.
Odho has since worked in many popular television and film projects and has been actively involved in both media and the cosmetic industry in Pakistan. She resides in the UAE and Pakistan.
Since 2009, she has also been engaged in philanthropic activities.[vague] She has been working for Shaukat Khanum Memorial Hospital,Fatmeed Foundation and as a social worker in "Hamara Mulk, Hamaray Log".[when?] She is currently the CEO of Odho Cosmetics, and Odho Productions. She is also the ambassador for the campaign on awareness of breast cancer in Pakistan.